Just another night with the fam

My brother and I were harassing my mother. Pretty standard operation. I don't remember what he said to warrant such a serious response but she came back with:

"I'll curse your colon."

My brother: --blank stare--
Me: --blank stare--

...

My brother: Well you know what mom? I wish only the best for your colon.

And no, there is absolutely NO context here. I have nothing to offer in the way of explanation. Nothing.